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PROVIDENCE, R.I., Sept. 2, 2026 /PRNewswire/ -- EpiVax, Inc. is pleased to announce the release of AI-enabled enhancements to ISPRI™, its proprietary in silico platform for assessing the immunogenicity risk of biotherapeutics. The release introduces an updated JanusMatrix™
For decades, EpiVax has pioneered computational immunology through the development of advanced in silico algorithms for evaluating biotherapeutic sequences. Foundational to this work are EpiMatrix® and JanusMatrix™, which evaluate T cell epitope content and human cross-conservation to characterize sequence-derived immunogenicity risk and immune tolerance. ISPRI™ brings these tools together with other extensively validated methods to assess immunogenicity risk across candidate and impurity sequences.
JanusMatrix™ 2.1JanusMatrix™ 2.1 applies AI to improve the prediction of immune tolerance by weighting human epitope cross-conservation based on expression and prevalence data. The result is a more precise characterization of therapeutic epitopes and their tolerance profiles.
JanusMatrix-Adjusted EpiMatrix ScoreBuilding on JanusMatrix 2.1, EpiVax has introduced a new immunogenicity score designed to align more closely with clinical immunogenicity outcomes. The JanusMatrix-Adjusted EpiMatrix (JAX) score incorporates JanusMatrix tolerance potential directly into EpiMatrix scores, providing insight into intrinsic effector epitope density and a more biologically-informed assessment of sequence-derived immunogenicity risk across therapeutic modalities.
ADA 2.2EpiVax has also updated its ADA prediction model with the release of ADA 2.2. The enhanced model combines epitope-based measures with biophysical attributes and mode of action criteria to provide another assessment of antibody immunogenicity risk, trained specifically leveraging a diverse set of clinical monoclonal antibodies. ADA 2.2 demonstrates a stronger correlation between predicted and clinically observed immunogenicity, providing greater confidence in risk interpretation alongside the JAX score.
These newly available features further strengthen EpiVax's best-in-class immunoinformatics capabilities, improving the relevance and predictive value of in silico immunogenicity risk assessments. The enhancements align closely with recent FDA initiatives advancing the adoption of human-relevant New Approach Methodologies (NAMs), while helping sponsors identify immune liabilities, protect asset value, and de-risk development programs.
About EpiVaxEpiVax partners with biologic developers to manage immunogenicity risk throughout the product lifecycle. Leveraging deep scientific expertise to apply industry-leading in silico analyses and in vitro approaches, insights from actionable data help our partners reduce uncertainty, mitigate risk, and use resources more efficiently while building regulatory-ready strategies for safer, more effective therapies.
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